If we look at layers of matter organization, from elementary particles (electrons, protons or lower) up to Life, we found an interesting steady progress in complexity and a decrease in physical durability.
For example atoms are very hard to break. We can do fission on Uranium and other unstable atoms, but generally it requires a huge amount of energy to break an atom's nucleus structure. Even harder and rare is to break a neutron in his components, this happens only in very high energy nuclear reactions.
When we go up on the complexity scale, we have molecules that are pretty stable by our norms, however most of them are easily broke by chemical reactions. Some molecules are very stable, however most of them can relatively easily lose their structure by chemical reactions.
Complex molecules, like organic amino-acids are even more fragile. Enzymes could modify them. Even ultraviolet Sun rays could easily damage their structure. However, such molecules could have their information replicated in other molecules, like in genetic chains of RNA and DNA.